Three possible causes need to be located: capsule shell, content characteristics and equipment.
Capsule shell
It is essential to ensure the quality of your empty capsule supply. Any fragile or deformed capsule shell would bring catastrophic effects. Test the capsule shell chemically and physically to rule out this factor.
Content Characteristics
This mainly causes the filling inaccuracy of capsule. Uniformity, fluidity and stickiness (especially for herbal medicine) of capsule content would affect capsule filling results. If powder adheres to the stick of capsule filling machine, batches of capsules will be less filled than the standard. To ameliorate the distribution of the active ingredient of capsule content and improve capsule filling process, proper addition of excipients or granulation of the raw material is applicable.
Equipment
According to the physical characteristics, choose appropriate capsule filling machine. Regular maintenance and overhaul for the equipment would decrease the risk of defects. Wear and tear of the filler fluctuating the fill weight must also be considered as a routine survey.
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Post time: Sep-30-2017